Nov 2, 2020 · Due to the finding of increased risk of relapse, cyclosporine should be administered as traditional twice daily infusion unless necessary
There are numerous important interactions - check BNF Must have access to facilities for managing hypersensitivity reactions including anaphylaxis - due to polyethoxylated castor oil Dose adjustments needed in renal impairment- specialist review required Low adsorption giving set and bag required Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients Jeff A Engle, Justin A Wasko, […], and Armin Rashidi +2 View all authors and affiliations Volume 27, Issue 8 Contents Get access More Related content Continuous infusion of ceftolozane-tazobactam showed a marked superiority toward both intermittent and extended infusion (EI) in achieving a PK/PD target of 100% f T > 4 X MIC in infections caused by less-susceptible Pseudomonas aeruginosa isolates
To compare the clinical efficacy and safety of continuous intravenous administration of concentration-dependent and time-dependent antibiotics with traditional intermittent intravenous administration in adults with severe acute bacterial infections
Objective: Due to the finding of increased risk of relapse, cyclosporine should be administered as traditional twice daily infusion unless necessary
An intermittent IV medication may be called a piggyback medication, a secondary medication, or a mini bag medication (see Figure 7
doi: 10
0000000000000755 A possible explanation for the better effectiveness in the continuous group is the higher tissue concentrations of β-lactam in this patient group than in the intermittent group Other studies had similar outcomes that showed an improved bacteriological efficacy associated with the continuous application of meropenem In the current study, the over Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients - Jeff A Engle, Justin A Wasko, John Rogosheske, Todd E Defor, Armin Rashidi, 2021 Resources Librarians Editors Societies Reviewers Advanced Search IN THIS JOURNAL Journal Home Browse Journal Current Issue Request PDF | Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients | Introduction: Continuous @article{Engle2020ComparisonOC, title={Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients}, author={Jeff A Engle and Justin A Wasko and John Rogosheske and Todd E
J Oncol Pharm Pract 2020
Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients - Jeff A Engle, Justin A Wasko, John Rogosheske, Todd E Defor, Armin Rashidi, 2021 5-Year Impact Factor: 1
It may be administered IV via continuous infusion or given over 2-6 hours
We did a meta-analysis of randomised controlled trials comparing continuous intravenous infusion with Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients Show all authors
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DeFor and Armin Rashidi}, journal={Journal of Oncology Pharmacy Practice}, year={2020 @article{Engle2020ComparisonOC, title={Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients}, author={Jeff A Engle and Justin A Wasko and John Rogosheske and Todd E
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Objectives: In this individual patient data meta-analysis of critically ill patients with severe sepsis, we aimed to compare clinical outcomes of those treated with continuous versus intermittent infusion of β-lactam antibiotics
The conclusion of our study appears to be inconsistent with those of the Continuous Infusion vs Intermittent Administration of Meropenem in Critically Ill Patients (MERCY) trial , the biggest RCT on this issue to date
Hence, continuous intravenous infusion was thought of as an alternative route of administration
This study aimed to assess the efficacy of prolonged versus intermittent β-lactam antibiotics infusion on outcomes in sepsis or septic shock patients by conducting a systematic review and meta-analysis
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6 greater odds of pharmacokinetic target attainment (odds ratio, 2
Total Regimen Costs for Five-Day Treatment of a Community-Acquired Intraabdominal Infection
Objective: To perform a systematic review and meta-analysis of the available literature comparing CI versus intermittent bolus (IB) of beta Continuous: 15 mg/kg IV load over 1 h, then 30 mg/kg daily IV over 24 h (dose adjusted to target Cplateau of 20-30 mg/L) Intermittent: 15 mg/kg IV over 1 h q12h (dose adjusted to target Ctr of 5-10 mg/L) Comparison of continuous v
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Although comparative studies of adult patients undergoing HSCT have demonstrated enhanced efficacy and safety of twice-daily infusion (TD) compared with continuous Objective: To comparatively assess the impact of intermittent and continuous cyclosporine (CyA) administration in chronic plaque psoriasis
However, there is no general consensus on whether continuous or bolus furosemide is safer or more effective in these hemodynamically unstable ICU patients
Accordingly, we performed 12-hour monitoring of blood concentrations to Sedative and analgesic drugs are used routinely on patients in the ICU who are mechanically ventilated
Introduction: Meropenem bactericidal activity depends on the time when the free drug concentrations remain above the minimum inhibitory concentration of pathogens
The focus was on studies that as
IntroductionContinuous infusion (CIVI) cyclosporine (CsA) is an alternative for allograft recipients intolerant of twice daily infusions (TDI)
Rationale for prolonged infusion of novel beta-lactams in the treatment of multidrug-resistant Gram-negative infections
Comparison of continuous and twice-daily infusions of cyclosporine A for graft-versus-host-disease prophylaxis in pediatric hematopoietic stem cell
Comparison of continuous versus intermittent infusion cyclosporine and impact on transplant related outcomes in allogeneic transplant recipients - Jeff A Engle
Currently, the recommended method of administration of IV tacrolimus is continuous (24 h) infusion because of high rates of neurologic and renal toxicities seen
Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent dosing
The prolonged β-lactam infusion strategy has emerged as the standard treatment for sepsis or septic shock despite its unknown efficacy
8) and with the low-dose strategy than with the high-dose strategy (12 vs
We conducted a systemic review and meta-analysis to evaluate the efficacy
We conducted a study comparing the continuous vancomycin infusion to the conventional intermittent infusion in critically ill intensive care unit patients and found that the continuous infusion provided better
Continuous beta-lactam infusion may be mostly advantageous for critically ill patients with high levels of illness severity and not receiving RRT
By tradition, it was administered as repeated intravenous boluses but fluctuations in intravascular volume and blood pressure were noticed in addition to the possibility of toxicity
1,A–F Days on extended infusion were significantly lower than intermittent infusion (5
10 Inspect the intravenous tacrolimus visually for particulate matter and discoloration prior to administration, whenever solution and container permit
gravity or by I
Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial
Bronchoalveolar lavage (BAL) was performed at steady state in both groups at 44 h to determine ceftazidime levels in the epithelial lining fluid
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Although comparative studies of adult patients undergoing HSCT have demonstrated enhanced efficacy and safety of