2 mg/kg/d for 3d may effectively achieve the goal of extubation
Routine dexamethasone therapy for all ventilator-dependent infants is not
5 mg/kg per day) is not recommended
Early treatment (prior to seven days after birth): Benefits:NMA for early treatment showed only moderate-dose dexamethasone to decrease the risk of BPD at
However, BPD at
98 mg/kg) in reducing BPD, follow-up studies of
We conducted a retrospective cohort study at the Women's Wellness and Research Center (WWRC) involving ELBW infants who received dexamethasone for
5 Low-dose dexamethasone treatment initiated after the first week of life has been found to facilitate extubation, shorten the duration of intubation and provide long-term benefits in infants at high risk of BPD
Of the different dexamethasone regimens, aggressive initiation seems beneficial, while a combination of high-dose and long-term use should be avoided because of the possible adverse neurodevelopmental outcome
to the treatment protocol of our medical center regarding the use of a corticosteroid for prevention or treatment of BPD, only dexamethasone was chosen as the treatment drug
Survival without moderate or severe bronchopulmonary dysplasia at 36 weeks occurred in 66 of 398 infants (16
2 mg/kg per day) may facilitate extubation and may decrease the incidence of short- and long-term adverse effects observed with higher doses of dexamethasone
In the Phase I portion, MTD was 120 mg/m2bendamustine/3mg pomalidomide/40mg dexamethasone
Design: A multicentre, randomised, masked, parallel-group, placebo-controlled Phase 2b trial
Budesonide
This “new BPD” demonstrated much less airway damage and alveolar septal fibrosis when compared to “old BPD” which was characterized by dysmorphic microvasculature and alveolar simplification
After four cycles, dexamethasone treatment was reduced to 20 mg
However, corticosteroids have also been associated with an increased risk of
There is no specific cure for BPD, but treatment focuses on minimizing further lung damage and providing support for the infant’s lungs, allowing them to heal and grow
OBJECTIVE
The use of postnatal corticosteroids to prevent bronchopulmonary dysplasia (BPD) is among the most controversial topics in neonatal medicine
2 mg/kg/d tapered over 7-12 days)